KDM5D | OmnibusX

Name	Number of supported studies	Average coverage
brain	3 studies	31% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	7837.82	245 / 245	100%	21.09	500 / 502
brain	70%	2478.44	1844 / 2642	56%	10.53	396 / 705
kidney	78%	3593.56	69 / 89	46%	5.58	413 / 901
bladder	67%	5600.86	14 / 21	53%	8.76	269 / 504
liver	71%	2080.83	161 / 226	48%	4.35	196 / 406
esophagus	66%	4762.15	952 / 1445	51%	6.09	93 / 183
lung	68%	4751.76	395 / 578	48%	6.76	552 / 1155
skin	67%	2938.05	1208 / 1809	49%	8.84	231 / 472
pancreas	63%	3390.59	207 / 328	52%	7.83	93 / 178
intestine	64%	5835.53	619 / 966	46%	5.31	244 / 527
stomach	64%	3862.96	228 / 359	39%	4.21	112 / 286
ureter	0%	0	0 / 0	100%	10.43	1 / 1
thymus	66%	5686.73	434 / 653	30%	7.66	180 / 605
adrenal gland	61%	8255.31	158 / 258	35%	5.84	80 / 230
tonsil	0%	0	0 / 0	71%	11.17	32 / 45
adipose	68%	4406.31	816 / 1204	0%	0	0 / 0
heart	68%	2607.99	583 / 861	0%	0	0 / 0
muscle	67%	2328.55	542 / 803	0%	0	0 / 0
blood vessel	66%	4605.37	879 / 1335	0%	0	0 / 0
breast	63%	3702.72	291 / 459	1%	0.18	10 / 1118
spleen	64%	8523.98	154 / 241	0%	0	0 / 0
peripheral blood	62%	2200.42	574 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	38%	7.28	11 / 29
eye	0%	0	0 / 0	33%	4.49	26 / 80
uterus	0%	0	0 / 170	7%	1.11	32 / 459
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0060765	Biological process	regulation of androgen receptor signaling pathway
GO_0006338	Biological process	chromatin remodeling
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0002457	Biological process	T cell antigen processing and presentation
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0001650	Cellular component	fibrillar center
GO_0005634	Cellular component	nucleus
GO_0032453	Molecular function	histone H3K4 demethylase activity
GO_0003677	Molecular function	DNA binding
GO_0032452	Molecular function	histone demethylase activity
GO_0050681	Molecular function	nuclear androgen receptor binding
GO_0034647	Molecular function	histone H3K4me/H3K4me2/H3K4me3 demethylase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

Gene name	KDM5D
Protein name	[histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) Lysine demethylase 5D Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D)
Synonyms	HYA SMCY HY JARID1D KIAA0234
Description	FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. .
Accessions	Q9BY66 ENST00000447300.1 ENST00000541639.5 [Q9BY66-3] ENST00000440077.5 H7BZF9 ENST00000415360.1 ENST00000317961.9 [Q9BY66-1] ENST00000382806.6 [Q9BY66-2] E9PFH2 C9JGA3

KDM5D report