KDM3A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	11 studies	28% ± 14%	Explore
endothelial cell	9 studies	28% ± 14%	Explore
microglial cell	6 studies	24% ± 7%	Explore
macrophage	5 studies	25% ± 9%	Explore
epithelial cell	4 studies	35% ± 12%	Explore
interneuron	3 studies	36% ± 17%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 4%	Explore
ciliated cell	3 studies	27% ± 7%	Explore
GABAergic neuron	3 studies	36% ± 6%	Explore
glutamatergic neuron	3 studies	44% ± 5%	Explore
ependymal cell	3 studies	31% ± 16%	Explore
fibroblast	3 studies	22% ± 10%	Explore
oligodendrocyte	3 studies	24% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	33% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	5934.29	180 / 180	100%	15.77	430 / 430
esophagus	100%	6181.31	1445 / 1445	99%	19.47	182 / 183
pancreas	100%	2993.06	328 / 328	99%	16.00	177 / 178
breast	100%	6425.78	459 / 459	99%	21.31	1111 / 1118
lung	100%	5501.62	576 / 578	99%	21.02	1149 / 1155
brain	99%	3442.10	2608 / 2642	100%	25.84	705 / 705
thymus	100%	6538.79	653 / 653	99%	16.25	596 / 605
intestine	100%	6334.93	966 / 966	98%	15.56	518 / 527
prostate	100%	5337.84	245 / 245	98%	13.68	493 / 502
uterus	100%	6168.31	170 / 170	98%	22.38	450 / 459
bladder	100%	6344.10	21 / 21	98%	16.37	494 / 504
stomach	100%	3735.39	359 / 359	98%	13.97	280 / 286
skin	100%	8607.43	1809 / 1809	97%	20.95	458 / 472
kidney	100%	3921.52	89 / 89	97%	18.27	870 / 901
adrenal gland	100%	3751.24	258 / 258	92%	11.60	211 / 230
liver	88%	1889.04	198 / 226	71%	6.30	287 / 406
adipose	100%	5784.88	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6792.41	1335 / 1335	0%	0	0 / 0
spleen	100%	4896.18	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	23.34	45 / 45
ureter	0%	0	0 / 0	100%	4.88	1 / 1
muscle	99%	3364.67	797 / 803	0%	0	0 / 0
heart	98%	3979.15	841 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	11.44	28 / 29
peripheral blood	96%	5140.89	895 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	88%	11.11	70 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046293	Biological process	formaldehyde biosynthetic process
GO_2000736	Biological process	regulation of stem cell differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_2000036	Biological process	regulation of stem cell population maintenance
GO_0006338	Biological process	chromatin remodeling
GO_0007290	Biological process	spermatid nucleus elongation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0009755	Biological process	hormone-mediated signaling pathway
GO_0030521	Biological process	androgen receptor signaling pathway
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0000118	Cellular component	histone deacetylase complex
GO_0005737	Cellular component	cytoplasm
GO_0001673	Cellular component	male germ cell nucleus
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0032454	Molecular function	histone H3K9 demethylase activity
GO_0140683	Molecular function	histone H3K9me/H3K9me2 demethylase activity
GO_0003712	Molecular function	transcription coregulator activity
GO_0005506	Molecular function	iron ion binding
GO_0050681	Molecular function	nuclear androgen receptor binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KDM3A
Protein name	Lysine-specific demethylase (EC 1.14.11.65) Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) Lysine demethylase 3A
Synonyms	JMJD1A TSGA JMJD1 JHDM2A KIAA0742
Description	FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. . FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. .
Accessions	F8WE62 ENST00000427678.1 C9J7Q7 ENST00000312912.10 ENST00000409064.5 ENST00000452034.5 Q9Y4C1 ENST00000441719.5 C9JC73 ENST00000409556.5

KDM3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review