KCTD17 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCTD17 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0045724Biological processpositive regulation of cilium assembly
GO_0030030Biological processcell projection organization
GO_0032469Biological processendoplasmic reticulum calcium ion homeostasis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0097602Molecular functioncullin family protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCTD17
Protein namePotassium channel tetramerization domain containing 17
BTB/POZ domain-containing protein KCTD17
Synonyms
DescriptionFUNCTION: Substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. Thereby, positively regulates ciliogenesis, playing a crucial role in the initial steps of axoneme extension . May also play a role in endoplasmic reticulum calcium ion homeostasis . .

AccessionsA0A087WX35
ENST00000456470.1
Q8N5Z5
ENST00000402077.8 [Q8N5Z5-2]
B0QYB2
H0Y731
H7C323
ENST00000431531.1
ENST00000403888.8 [Q8N5Z5-1]
ENST00000421900.5
ENST00000610767.5