KCNK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030322Biological processstabilization of membrane potential
GO_0006813Biological processpotassium ion transport
GO_0071805Biological processpotassium ion transmembrane transport
GO_0035094Biological processresponse to nicotine
GO_0060075Biological processregulation of resting membrane potential
GO_0035725Biological processsodium ion transmembrane transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0043204Cellular componentperikaryon
GO_0097060Cellular componentsynaptic membrane
GO_0034705Cellular componentpotassium channel complex
GO_1902937Cellular componentinward rectifier potassium channel complex
GO_0030425Cellular componentdendrite
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005272Molecular functionsodium channel activity
GO_0015271Molecular functionoutward rectifier potassium channel activity
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0022841Molecular functionpotassium ion leak channel activity
GO_0042802Molecular functionidentical protein binding
GO_0005242Molecular functioninward rectifier potassium channel activity
GO_0005267Molecular functionpotassium channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNK1
Protein namePotassium channel subfamily K member 1
Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1)
SynonymsHOHO1
KCNO1
TWIK1
DescriptionFUNCTION: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues . Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium . The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel . Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity . Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents . Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation . The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes . .

AccessionsENST00000446915.1
O00180
Q5T5E6
ENST00000366621.8