Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 12 studies | 28% ± 12% | |
retina horizontal cell | 5 studies | 42% ± 13% | |
endothelial cell | 3 studies | 27% ± 6% |
Insufficient scRNA-seq data for expression of KCNJ2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 98% | 466.31 | 564 / 578 | 79% | 7.21 | 911 / 1155 |
breast | 97% | 1064.33 | 446 / 459 | 72% | 3.87 | 806 / 1118 |
brain | 88% | 560.09 | 2315 / 2642 | 80% | 4.65 | 567 / 705 |
thymus | 78% | 170.25 | 507 / 653 | 87% | 21.15 | 524 / 605 |
esophagus | 96% | 388.32 | 1386 / 1445 | 68% | 3.94 | 124 / 183 |
intestine | 76% | 347.78 | 737 / 966 | 79% | 5.24 | 416 / 527 |
prostate | 92% | 273.07 | 225 / 245 | 62% | 2.73 | 313 / 502 |
stomach | 67% | 165.06 | 240 / 359 | 72% | 4.68 | 206 / 286 |
skin | 92% | 304.12 | 1671 / 1809 | 40% | 1.74 | 188 / 472 |
kidney | 51% | 119.33 | 45 / 89 | 77% | 8.72 | 694 / 901 |
uterus | 51% | 108.14 | 86 / 170 | 62% | 4.42 | 283 / 459 |
adrenal gland | 47% | 85.23 | 121 / 258 | 54% | 3.75 | 125 / 230 |
spleen | 100% | 1503.52 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 97% | 840.00 | 831 / 861 | 0% | 0 | 0 / 0 |
adipose | 95% | 344.11 | 1139 / 1204 | 0% | 0 | 0 / 0 |
muscle | 94% | 393.27 | 757 / 803 | 0% | 0 | 0 / 0 |
bladder | 38% | 111.57 | 8 / 21 | 49% | 3.62 | 246 / 504 |
ovary | 53% | 93.42 | 96 / 180 | 33% | 1.17 | 140 / 430 |
tonsil | 0% | 0 | 0 / 0 | 76% | 7.75 | 34 / 45 |
peripheral blood | 69% | 2345.58 | 645 / 929 | 0% | 0 | 0 / 0 |
pancreas | 4% | 5.23 | 12 / 328 | 53% | 2.33 | 94 / 178 |
lymph node | 0% | 0 | 0 / 0 | 41% | 3.39 | 12 / 29 |
blood vessel | 34% | 69.89 | 459 / 1335 | 0% | 0 | 0 / 0 |
liver | 16% | 23.93 | 37 / 226 | 16% | 0.59 | 64 / 406 |
eye | 0% | 0 | 0 / 0 | 18% | 0.70 | 14 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0086012 | Biological process | membrane depolarization during cardiac muscle cell action potential |
GO_1901381 | Biological process | positive regulation of potassium ion transmembrane transport |
GO_0006813 | Biological process | potassium ion transport |
GO_0014861 | Biological process | regulation of skeletal muscle contraction via regulation of action potential |
GO_0071260 | Biological process | cellular response to mechanical stimulus |
GO_0086002 | Biological process | cardiac muscle cell action potential involved in contraction |
GO_0086004 | Biological process | regulation of cardiac muscle cell contraction |
GO_0086011 | Biological process | membrane repolarization during action potential |
GO_0055119 | Biological process | relaxation of cardiac muscle |
GO_0086013 | Biological process | membrane repolarization during cardiac muscle cell action potential |
GO_0071805 | Biological process | potassium ion transmembrane transport |
GO_0034765 | Biological process | regulation of monoatomic ion transmembrane transport |
GO_0060306 | Biological process | regulation of membrane repolarization |
GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
GO_0015693 | Biological process | magnesium ion transport |
GO_0030007 | Biological process | intracellular potassium ion homeostasis |
GO_0060075 | Biological process | regulation of resting membrane potential |
GO_0090076 | Biological process | relaxation of skeletal muscle |
GO_1990573 | Biological process | potassium ion import across plasma membrane |
GO_0051289 | Biological process | protein homotetramerization |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005886 | Cellular component | plasma membrane |
GO_0043197 | Cellular component | dendritic spine |
GO_0016020 | Cellular component | membrane |
GO_0043025 | Cellular component | neuronal cell body |
GO_0030315 | Cellular component | T-tubule |
GO_0045211 | Cellular component | postsynaptic membrane |
GO_0008076 | Cellular component | voltage-gated potassium channel complex |
GO_0014704 | Cellular component | intercalated disc |
GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0086008 | Molecular function | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization |
GO_0005242 | Molecular function | inward rectifier potassium channel activity |
GO_0005515 | Molecular function | protein binding |
Gene name | KCNJ2 |
Protein name | Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2) |
Synonyms | IRK1 |
Description | FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues . Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it . Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages . The inward rectification is mainly due to the blockage of outward current by internal magnesium . Can be blocked by extracellular barium or cesium . . |
Accessions | ENST00000243457.4 P63252 ENST00000535240.1 |