KCNA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0014059Biological processregulation of dopamine secretion
GO_0051260Biological processprotein homooligomerization
GO_0006813Biological processpotassium ion transport
GO_0045188Biological processregulation of circadian sleep/wake cycle, non-REM sleep
GO_0021633Biological processoptic nerve structural organization
GO_0071805Biological processpotassium ion transmembrane transport
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0097623Biological processpotassium ion export across plasma membrane
GO_0019228Biological processneuronal action potential
GO_0022038Biological processcorpus callosum development
GO_0060078Biological processregulation of postsynaptic membrane potential
GO_0021987Biological processcerebral cortex development
GO_0001508Biological processaction potential
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043204Cellular componentperikaryon
GO_0043679Cellular componentaxon terminus
GO_0043194Cellular componentaxon initial segment
GO_0032809Cellular componentneuronal cell body membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0031258Cellular componentlamellipodium membrane
GO_0044305Cellular componentcalyx of Held
GO_0033010Cellular componentparanodal junction
GO_0044224Cellular componentjuxtaparanode region of axon
GO_0045211Cellular componentpostsynaptic membrane
GO_0030424Cellular componentaxon
GO_0030027Cellular componentlamellipodium
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0015271Molecular functionoutward rectifier potassium channel activity
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_1905030Molecular functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0099508Molecular functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0005267Molecular functionpotassium channel activity
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameKCNA2
Protein namePotassium voltage-gated channel subfamily A member 2
Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)
Synonyms
DescriptionFUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel . Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure . In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation . Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity). .

AccessionsENST00000638532.1 [P16389-1]
ENST00000638616.2 [P16389-1]
ENST00000316361.10 [P16389-1]
ENST00000640956.1
A0A1W2PR01
ENST00000369770.7 [P16389-2]
ENST00000640774.2
A0A1W2PRY2
ENST00000639048.2
P16389
ENST00000639233.2
ENST00000675391.1 [P16389-1]
ENST00000485317.6 [P16389-1]
ENST00000638477.2
A0A1W2PP65
A0A1W2PPN8
A0A1W2PPM7
ENST00000633222.1 [P16389-1]