KAT7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0032786Biological processpositive regulation of DNA-templated transcription, elongation
GO_0001558Biological processregulation of cell growth
GO_0001779Biological processnatural killer cell differentiation
GO_0072710Biological processresponse to hydroxyurea
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1902035Biological processpositive regulation of hematopoietic stem cell proliferation
GO_0018393Biological processinternal peptidyl-lysine acetylation
GO_0006260Biological processDNA replication
GO_0072716Biological processresponse to actinomycin D
GO_0072739Biological processresponse to anisomycin
GO_0045740Biological processpositive regulation of DNA replication
GO_0140889Biological processDNA replication-dependent chromatin disassembly
GO_0030174Biological processregulation of DNA-templated DNA replication initiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_2000278Biological processregulation of DNA biosynthetic process
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0072708Biological processresponse to sorbitol
GO_0031098Biological processstress-activated protein kinase signaling cascade
GO_0072720Biological processresponse to dithiothreitol
GO_0006275Biological processregulation of DNA replication
GO_0051726Biological processregulation of cell cycle
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0000775Cellular componentchromosome, centromeric region
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0036409Cellular componenthistone H3-K14 acetyltransferase complex
GO_0005829Cellular componentcytosol
GO_0005694Cellular componentchromosome
GO_0000785Cellular componentchromatin
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0043997Molecular functionhistone H4K12 acetyltransferase activity
GO_0036408Molecular functionhistone H3K14 acetyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0003688Molecular functionDNA replication origin binding
GO_0043994Molecular functionhistone H3K23 acetyltransferase activity
GO_0046972Molecular functionhistone H4K16 acetyltransferase activity
GO_0010484Molecular functionhistone H3 acetyltransferase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0044016Molecular functionhistone H3K4 acetyltransferase activity
GO_0043996Molecular functionhistone H4K8 acetyltransferase activity
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0043995Molecular functionhistone H4K5 acetyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKAT7
Protein nameHistone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)
histone acetyltransferase (EC 2.3.1.48)
Lysine acetyltransferase 7
SynonymsHBOa
hCG_2001877
MYST2
HBO1
DescriptionFUNCTION: Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development . Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation . Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 . H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II . Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation . H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing . Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange . Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites . Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity . .; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) . Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells . .

AccessionsENST00000706506.1 [O95251-4]
ENST00000706638.1
ENST00000509773.5 [O95251-2]
A0A9L9PXM0
A0A9L9PX04
A0A9L9PXR4
ENST00000513171.5
A0A9L9PXL5
A0A9L9PWZ9
E7EUP3
ENST00000424009.6 [O95251-4]
O95251
ENST00000706640.1
ENST00000706637.1
A0A9L9PX81
A0A9L9PXJ9
ENST00000259021.9 [O95251-1]
ENST00000710381.1
ENST00000506533.6
ENST00000706629.1
ENST00000706508.1
A0A9L9PXP8
ENST00000675278.1
A0A9L9PXC5
ENST00000514540.6
ENST00000706513.1
A0A9L9PY29
ENST00000510819.5 [O95251-3]
D6RFZ5
A0A6Q8PHH2
ENST00000706642.1
ENST00000706509.1
A0A9L9PXR9
ENST00000454930.6 [O95251-5]
ENST00000435742.2
A0AA34QVH8
ENST00000503635.2
B4DGH8
ENST00000706511.1