KASH5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KASH5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KASH5 at tissue level.

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0034397Biological processtelomere localization
GO_0090220Biological processchromosome localization to nuclear envelope involved in homologous chromosome segregation
GO_0007283Biological processspermatogenesis
GO_0051653Biological processspindle localization
GO_0051225Biological processspindle assembly
GO_0048477Biological processoogenesis
GO_0007015Biological processactin filament organization
GO_0045141Biological processmeiotic telomere clustering
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0000800Cellular componentlateral element
GO_0034993Cellular componentmeiotic nuclear membrane microtubule tethering complex
GO_0090619Cellular componentmeiotic spindle pole
GO_0000781Cellular componentchromosome, telomeric region
GO_0005640Cellular componentnuclear outer membrane
GO_0070840Molecular functiondynein complex binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKASH5
Protein nameKASH domain containing 5
Protein KASH5 (Coiled-coil domain-containing protein 155) (KASH domain-containing protein 5)
SynonymsCCDC155
DescriptionFUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. .

AccessionsENST00000600570.1
ENST00000597993.5
M0QXW9
M0R1C7
ENST00000598730.5
M0QXT3
M0QZT9
ENST00000594043.5
ENST00000595828.5
M0QX09
Q8N6L0
M0QZW6
ENST00000447857.8
ENST00000594905.5