JMY report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0070358Biological processactin polymerization-dependent cell motility
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070060Biological process'de novo' actin filament nucleation
GO_0009267Biological processcellular response to starvation
GO_0034314Biological processArp2/3 complex-mediated actin nucleation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005856Cellular componentcytoskeleton
GO_0031410Cellular componentcytoplasmic vesicle
GO_0012505Cellular componentendomembrane system
GO_0000421Cellular componentautophagosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0031252Cellular componentcell leading edge
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0071933Molecular functionArp2/3 complex binding
GO_0008017Molecular functionmicrotubule binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameJMY
Protein nameJunction-mediating and -regulatory protein
Synonyms
DescriptionFUNCTION: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions . In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments . Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments . Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy . The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). .

AccessionsQ8N9B5
ENST00000396137.5 [Q8N9B5-1]