IWS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050684Biological processregulation of mRNA processing
GO_0010793Biological processregulation of mRNA export from nucleus
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0016973Biological processpoly(A)+ mRNA export from nucleus
GO_0140673Biological processtranscription elongation-coupled chromatin remodeling
GO_0006338Biological processchromatin remodeling
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIWS1
Protein nameInteracts with SUPT6H, CTD assembly factor 1
IWS1 protein
Protein IWS1 homolog (IWS1-like protein)
SynonymsIWS1L
DescriptionFUNCTION: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. .

AccessionsQ7L2V5
H7C0U1
ENST00000295321.9 [Q96ST2-1]
ENST00000637187.2
ENST00000409725.1
B8ZZB6
ENST00000412979.1
Q96ST2
A0A1B0GW95