Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 25% ± 11% | |
oligodendrocyte | 11 studies | 36% ± 13% | |
astrocyte | 9 studies | 29% ± 15% | |
fibroblast | 8 studies | 20% ± 5% | |
epithelial cell | 7 studies | 32% ± 14% | |
adipocyte | 7 studies | 22% ± 4% | |
ciliated cell | 7 studies | 22% ± 7% | |
macrophage | 7 studies | 23% ± 6% | |
natural killer cell | 6 studies | 17% ± 2% | |
microglial cell | 6 studies | 27% ± 9% | |
type I pneumocyte | 6 studies | 21% ± 5% | |
GABAergic neuron | 6 studies | 33% ± 18% | |
type II pneumocyte | 5 studies | 20% ± 4% | |
oligodendrocyte precursor cell | 5 studies | 28% ± 13% | |
dendritic cell | 5 studies | 26% ± 10% | |
hematopoietic precursor cell | 4 studies | 20% ± 3% | |
myeloid cell | 4 studies | 21% ± 5% | |
B cell | 4 studies | 20% ± 4% | |
lymphocyte | 4 studies | 22% ± 4% | |
glutamatergic neuron | 4 studies | 46% ± 16% | |
monocyte | 4 studies | 21% ± 1% | |
endothelial cell of lymphatic vessel | 4 studies | 21% ± 5% | |
interneuron | 4 studies | 39% ± 23% | |
neuron | 4 studies | 39% ± 15% | |
retinal cone cell | 3 studies | 23% ± 2% | |
respiratory goblet cell | 3 studies | 24% ± 7% | |
hepatocyte | 3 studies | 41% ± 20% | |
CD8-positive, alpha-beta T cell | 3 studies | 18% ± 3% | |
ependymal cell | 3 studies | 36% ± 14% | |
club cell | 3 studies | 22% ± 2% | |
T cell | 3 studies | 18% ± 2% | |
pericyte | 3 studies | 20% ± 5% | |
basal cell | 3 studies | 29% ± 5% | |
goblet cell | 3 studies | 30% ± 17% | |
transit amplifying cell | 3 studies | 24% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2964.35 | 1445 / 1445 | 100% | 38.40 | 183 / 183 |
intestine | 100% | 3193.78 | 966 / 966 | 100% | 40.40 | 527 / 527 |
lung | 100% | 3162.55 | 578 / 578 | 100% | 44.67 | 1155 / 1155 |
pancreas | 100% | 1407.38 | 328 / 328 | 100% | 43.39 | 178 / 178 |
prostate | 100% | 3134.29 | 245 / 245 | 100% | 40.40 | 502 / 502 |
stomach | 100% | 2299.38 | 359 / 359 | 100% | 36.41 | 286 / 286 |
uterus | 100% | 3296.14 | 170 / 170 | 100% | 48.32 | 459 / 459 |
breast | 100% | 3186.48 | 459 / 459 | 100% | 48.24 | 1117 / 1118 |
brain | 100% | 2436.45 | 2639 / 2642 | 100% | 47.92 | 705 / 705 |
bladder | 100% | 2994.76 | 21 / 21 | 100% | 41.76 | 503 / 504 |
liver | 100% | 2332.31 | 226 / 226 | 100% | 28.03 | 404 / 406 |
thymus | 100% | 3092.03 | 653 / 653 | 100% | 43.89 | 602 / 605 |
skin | 100% | 3200.71 | 1809 / 1809 | 99% | 45.60 | 468 / 472 |
kidney | 100% | 2681.97 | 89 / 89 | 99% | 29.31 | 893 / 901 |
ovary | 100% | 2375.07 | 180 / 180 | 99% | 27.28 | 426 / 430 |
adrenal gland | 100% | 2220.05 | 258 / 258 | 97% | 28.63 | 222 / 230 |
adipose | 100% | 3130.53 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 49.39 | 29 / 29 |
muscle | 100% | 3885.26 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3550.59 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 40.94 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 10.73 | 1 / 1 |
blood vessel | 100% | 2779.72 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 2807.50 | 852 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 2390.45 | 898 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 28.69 | 76 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0050684 | Biological process | regulation of mRNA processing |
GO_0010793 | Biological process | regulation of mRNA export from nucleus |
GO_0008380 | Biological process | RNA splicing |
GO_0006397 | Biological process | mRNA processing |
GO_0016973 | Biological process | poly(A)+ mRNA export from nucleus |
GO_0140673 | Biological process | transcription elongation-coupled chromatin remodeling |
GO_0006338 | Biological process | chromatin remodeling |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
Gene name | IWS1 |
Protein name | Interacts with SUPT6H, CTD assembly factor 1 IWS1 protein Protein IWS1 homolog (IWS1-like protein) |
Synonyms | IWS1L |
Description | FUNCTION: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. . |
Accessions | Q7L2V5 H7C0U1 ENST00000295321.9 [Q96ST2-1] ENST00000637187.2 ENST00000409725.1 B8ZZB6 ENST00000412979.1 Q96ST2 A0A1B0GW95 |