ISY1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ISY1 at tissue level.

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000350Biological processgeneration of catalytic spliceosome for second transesterification step
GO_0000389Biological processmRNA 3'-splice site recognition
GO_0071014Cellular componentpost-mRNA release spliceosomal complex
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005654Cellular componentnucleoplasm
GO_0071020Cellular componentpost-spliceosomal complex
GO_0000974Cellular componentPrp19 complex
GO_0071006Cellular componentU2-type catalytic step 1 spliceosome
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameISY1
Protein namePre-mRNA-splicing factor ISY1 homolog
ISY1 splicing factor homolog
SynonymsKIAA1160
DescriptionFUNCTION: Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome. .

AccessionsENST00000273541.12 [Q9ULR0-2]
ENST00000393295.8 [Q9ULR0-3]
D6RC18
ENST00000485703.1
H0YA89
ENST00000496163.5
ENST00000393292.7
Q9ULR0
A8MVI5