IQUB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IQUB at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0007618Biological processmating
GO_0007224Biological processsmoothened signaling pathway
GO_0030317Biological processflagellated sperm motility
GO_0031514Cellular componentmotile cilium
GO_0001534Cellular componentradial spoke
GO_0001669Cellular componentacrosomal vesicle
GO_0036126Cellular componentsperm flagellum
GO_0097729Cellular component9+2 motile cilium
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIQUB
Protein nameIQ motif and ubiquitin-like domain-containing protein
IQ motif and ubiquitin domain containing (IQUB protein)
Synonyms
DescriptionFUNCTION: Adapter protein that anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes . The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum . May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1 . Additionally, may play a role in the functioning of cilia (By similarity). Not required for the functioning of tracheal or ependymal cilia (By similarity). .

AccessionsQ8NA54
ENST00000469057.1
ENST00000324698.11 [Q8NA54-1]
ENST00000484508.5 [Q8NA54-2]
A1A4Z1
ENST00000466202.5 [Q8NA54-1]