IPO5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0006606Biological processprotein import into nucleus
GO_0071230Biological processcellular response to amino acid stimulus
GO_0006610Biological processribosomal protein import into nucleus
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_0005730Cellular componentnucleolus
GO_0005643Cellular componentnuclear pore
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0005095Molecular functionGTPase inhibitor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0061608Molecular functionnuclear import signal receptor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIPO5
Protein nameImportin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Importin 5
IPO5 protein
SynonymsKPNB3
RANBP5
DescriptionFUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 . In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. .

AccessionsE7EWK4
ENST00000489058.6
ENST00000485433.6
ENST00000480641.2
ENST00000490369.6
H0Y3V4
H0Y8C6
ENST00000493281.6
E7ETV3
C9JXE0
ENST00000261574.10 [O00410-3]
ENST00000631030.1
ENST00000469360.5
ENST00000490680.5 [O00410-1]
E7EV12
C9JZD8
ENST00000496368.6
ENST00000481689.6
Q9BVS9
ENST00000475420.5
ENST00000651721.2 [O00410-1]
C9J875
C9JQT6
C9JZ53
ENST00000460070.6
ENST00000463157.6
ENST00000421861.7
ENST00000471898.5
ENST00000481455.6
C9J583
E7ESZ1
F8WF30
E7EQT5
ENST00000497270.5
ENST00000403772.8
E7ETV8
A0A0D9SG25
O00410
E7EX05
ENST00000480611.6
ENST00000357602.7 [O00410-1]