Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 10 studies | 19% ± 3% | |
endothelial cell | 9 studies | 25% ± 7% | |
glutamatergic neuron | 7 studies | 38% ± 24% | |
smooth muscle cell | 6 studies | 17% ± 1% | |
epithelial cell | 6 studies | 35% ± 14% | |
pericyte | 5 studies | 19% ± 2% | |
astrocyte | 5 studies | 27% ± 8% | |
hematopoietic precursor cell | 4 studies | 23% ± 6% | |
neuron | 4 studies | 27% ± 8% | |
myofibroblast cell | 4 studies | 17% ± 2% | |
basal cell | 4 studies | 25% ± 10% | |
oligodendrocyte precursor cell | 4 studies | 24% ± 6% | |
oligodendrocyte | 4 studies | 25% ± 6% | |
neural crest cell | 3 studies | 21% ± 3% | |
ciliated cell | 3 studies | 26% ± 7% | |
GABAergic neuron | 3 studies | 47% ± 1% | |
dendritic cell | 3 studies | 29% ± 9% | |
intestinal crypt stem cell | 3 studies | 21% ± 4% | |
transit amplifying cell | 3 studies | 33% ± 11% | |
plasmacytoid dendritic cell | 3 studies | 20% ± 3% | |
erythroblast | 3 studies | 41% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 13171.62 | 180 / 180 | 100% | 49.52 | 430 / 430 |
pancreas | 100% | 10153.27 | 328 / 328 | 100% | 42.32 | 178 / 178 |
stomach | 100% | 7740.74 | 359 / 359 | 100% | 79.01 | 286 / 286 |
esophagus | 100% | 8485.90 | 1444 / 1445 | 100% | 70.29 | 183 / 183 |
breast | 100% | 8976.25 | 459 / 459 | 100% | 63.07 | 1117 / 1118 |
prostate | 100% | 7538.93 | 245 / 245 | 100% | 49.03 | 501 / 502 |
uterus | 100% | 10438.98 | 170 / 170 | 100% | 61.16 | 458 / 459 |
intestine | 100% | 8925.52 | 964 / 966 | 100% | 82.05 | 526 / 527 |
bladder | 100% | 10114.81 | 21 / 21 | 100% | 62.30 | 502 / 504 |
lung | 100% | 7765.98 | 576 / 578 | 100% | 53.59 | 1154 / 1155 |
thymus | 100% | 7943.83 | 653 / 653 | 100% | 54.53 | 602 / 605 |
brain | 99% | 6595.13 | 2626 / 2642 | 100% | 69.19 | 705 / 705 |
kidney | 100% | 6541.09 | 89 / 89 | 98% | 44.17 | 882 / 901 |
skin | 100% | 12018.06 | 1808 / 1809 | 97% | 69.26 | 460 / 472 |
liver | 99% | 4002.51 | 224 / 226 | 94% | 31.45 | 383 / 406 |
adrenal gland | 100% | 5988.08 | 258 / 258 | 91% | 31.86 | 210 / 230 |
adipose | 100% | 10160.06 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 10408.73 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 64.07 | 29 / 29 |
muscle | 100% | 17669.31 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5725.51 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 47.50 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.11 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 96% | 51.33 | 77 / 80 |
heart | 94% | 6989.25 | 809 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 36% | 4773.19 | 338 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0042307 | Biological process | positive regulation of protein import into nucleus |
GO_0006606 | Biological process | protein import into nucleus |
GO_0071230 | Biological process | cellular response to amino acid stimulus |
GO_0006610 | Biological process | ribosomal protein import into nucleus |
GO_0045736 | Biological process | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
GO_0002753 | Biological process | cytoplasmic pattern recognition receptor signaling pathway |
GO_0006607 | Biological process | NLS-bearing protein import into nucleus |
GO_0005730 | Cellular component | nucleolus |
GO_0005643 | Cellular component | nuclear pore |
GO_0016020 | Cellular component | membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0031965 | Cellular component | nuclear membrane |
GO_0005634 | Cellular component | nucleus |
GO_0008139 | Molecular function | nuclear localization sequence binding |
GO_0005095 | Molecular function | GTPase inhibitor activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0061608 | Molecular function | nuclear import signal receptor activity |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | IPO5 |
Protein name | Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) Importin 5 IPO5 protein |
Synonyms | KPNB3 RANBP5 |
Description | FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 . In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. . |
Accessions | E7EWK4 ENST00000489058.6 ENST00000485433.6 ENST00000480641.2 ENST00000490369.6 H0Y3V4 H0Y8C6 ENST00000493281.6 E7ETV3 C9JXE0 ENST00000261574.10 [O00410-3] ENST00000631030.1 ENST00000469360.5 ENST00000490680.5 [O00410-1] E7EV12 C9JZD8 ENST00000496368.6 ENST00000481689.6 Q9BVS9 ENST00000475420.5 ENST00000651721.2 [O00410-1] C9J875 C9JQT6 C9JZ53 ENST00000460070.6 ENST00000463157.6 ENST00000421861.7 ENST00000471898.5 ENST00000481455.6 C9J583 E7ESZ1 F8WF30 E7EQT5 ENST00000497270.5 ENST00000403772.8 E7ETV8 A0A0D9SG25 O00410 E7EX05 ENST00000480611.6 ENST00000357602.7 [O00410-1] |