INSRR report

I. Expression across cell types

Insufficient scRNA-seq data for expression of INSRR at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of INSRR at tissue level.

III. Associated gene sets

GO_0033674Biological processpositive regulation of kinase activity
GO_0030036Biological processactin cytoskeleton organization
GO_0007275Biological processmulticellular organism development
GO_0071469Biological processcellular response to alkaline pH
GO_0008286Biological processinsulin receptor signaling pathway
GO_0030238Biological processmale sex determination
GO_0046777Biological processprotein autophosphorylation
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0005899Cellular componentinsulin receptor complex
GO_0030424Cellular componentaxon
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005009Molecular functioninsulin receptor activity
GO_0005524Molecular functionATP binding
GO_0043548Molecular functionphosphatidylinositol 3-kinase binding
GO_0005515Molecular functionprotein binding
GO_0043560Molecular functioninsulin receptor substrate binding
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity

IV. Literature review

[source]
Gene nameINSRR
Protein nameInsulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
receptor protein-tyrosine kinase (EC 2.7.10.1)
SynonymsIRR
DescriptionFUNCTION: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. .

AccessionsI6U4P1
P14616
ENST00000368195.4