INSIG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042472Biological processinner ear morphogenesis
GO_0010894Biological processnegative regulation of steroid biosynthetic process
GO_0036316Biological processSREBP-SCAP complex retention in endoplasmic reticulum
GO_0042474Biological processmiddle ear morphogenesis
GO_0032933Biological processSREBP signaling pathway
GO_0060021Biological processroof of mouth development
GO_0006695Biological processcholesterol biosynthetic process
GO_0032869Biological processcellular response to insulin stimulus
GO_0060363Biological processcranial suture morphogenesis
GO_0006641Biological processtriglyceride metabolic process
GO_0045717Biological processnegative regulation of fatty acid biosynthetic process
GO_0032937Cellular componentSREBP-SCAP-Insig complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0140311Molecular functionprotein sequestering activity
GO_0005515Molecular functionprotein binding
GO_0008142Molecular functionoxysterol binding

IV. Literature review

[source]
Gene nameINSIG2
Protein nameInsulin induced gene 2
Insulin-induced gene 2 protein (INSIG-2)
Synonyms
DescriptionFUNCTION: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR . Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 . Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum . In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi . Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 . Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 . .

AccessionsQ9Y5U4
ENST00000245787.9
ENST00000411929.5
F8WCG8