INPP5F report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0001921Biological processpositive regulation of receptor recycling
GO_0014898Biological processcardiac muscle hypertrophy in response to stress
GO_0031161Biological processphosphatidylinositol catabolic process
GO_0008344Biological processadult locomotory behavior
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_2000145Biological processregulation of cell motility
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0072583Biological processclathrin-dependent endocytosis
GO_0048681Biological processnegative regulation of axon regeneration
GO_0042532Biological processnegative regulation of tyrosine phosphorylation of STAT protein
GO_2001135Biological processregulation of endocytic recycling
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005905Cellular componentclathrin-coated pit
GO_0030424Cellular componentaxon
GO_0042803Molecular functionprotein homodimerization activity
GO_0034595Molecular functionphosphatidylinositol phosphate 5-phosphatase activity
GO_0034596Molecular functionphosphatidylinositol phosphate 4-phosphatase activity
GO_0052833Molecular functioninositol monophosphate 4-phosphatase activity
GO_0043812Molecular functionphosphatidylinositol-4-phosphate phosphatase activity
GO_0008934Molecular functioninositol monophosphate 1-phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0052832Molecular functioninositol monophosphate 3-phosphatase activity

IV. Literature review

[source]
Gene nameINPP5F
Protein nameInositol polyphosphate-5-phosphatase F
Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2)
SynonymsKIAA0966
MSTP047
MSTP007
SAC2
DescriptionFUNCTION: Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling . Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms . Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation . Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus . Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). .

AccessionsA0A0J9YWP2
A0A0J9YYL5
ENST00000649251.1
ENST00000648262.1
ENST00000490818.1
ENST00000650305.1
A0A0J9YY79
A0A3B3IRT4
ENST00000631485.1
ENST00000648621.1
A0A3B3IS29
ENST00000649742.1
ENST00000649297.1
ENST00000648515.1
A0A3B3ITL0
ENST00000648661.1
ENST00000650409.1 [Q9Y2H2-4]
A0A3B3ISI3
ENST00000647699.1
A0A3B3IS98
ENST00000637174.1
ENST00000650623.2 [Q9Y2H2-1]
ENST00000369081.3 [Q9Y2H2-3]
A0A3B3IU10
ENST00000631555.1
A0A0J9YVW6
A0A3B3IRJ9
ENST00000649454.1
A0A3B3ISK0
ENST00000631572.1
A0A3B3ITR9
ENST00000647933.1
Q9Y2H2
A0A1B0GUS5
A0A3B3ISG0
A0A3B3ISJ5
ENST00000649957.1