Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 11 studies | 30% ± 11% | |
GABAergic neuron | 10 studies | 48% ± 23% | |
oligodendrocyte precursor cell | 10 studies | 25% ± 11% | |
glutamatergic neuron | 10 studies | 46% ± 20% | |
endothelial cell | 7 studies | 29% ± 15% | |
neuron | 6 studies | 34% ± 7% | |
interneuron | 6 studies | 51% ± 22% | |
oligodendrocyte | 6 studies | 27% ± 9% | |
microglial cell | 5 studies | 25% ± 6% | |
dendritic cell | 5 studies | 19% ± 4% | |
GABAergic interneuron | 3 studies | 40% ± 5% | |
glial cell | 3 studies | 23% ± 1% | |
granule cell | 3 studies | 26% ± 1% | |
macrophage | 3 studies | 25% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 13 studies | 35% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 11607.50 | 2626 / 2642 | 100% | 28.11 | 705 / 705 |
skin | 99% | 1952.28 | 1788 / 1809 | 99% | 60.30 | 467 / 472 |
esophagus | 96% | 1793.23 | 1392 / 1445 | 99% | 11.80 | 181 / 183 |
uterus | 99% | 2832.01 | 169 / 170 | 95% | 16.38 | 435 / 459 |
thymus | 97% | 1502.86 | 635 / 653 | 97% | 18.16 | 584 / 605 |
lung | 97% | 1586.31 | 559 / 578 | 96% | 11.64 | 1111 / 1155 |
breast | 95% | 1447.30 | 438 / 459 | 97% | 14.07 | 1086 / 1118 |
prostate | 99% | 1950.26 | 243 / 245 | 92% | 7.79 | 460 / 502 |
bladder | 100% | 1697.19 | 21 / 21 | 89% | 8.11 | 449 / 504 |
intestine | 96% | 2188.53 | 923 / 966 | 90% | 7.68 | 474 / 527 |
ovary | 98% | 1724.12 | 177 / 180 | 86% | 7.22 | 369 / 430 |
kidney | 89% | 1421.98 | 79 / 89 | 82% | 8.12 | 738 / 901 |
stomach | 51% | 1023.89 | 184 / 359 | 89% | 8.12 | 255 / 286 |
adrenal gland | 50% | 769.86 | 128 / 258 | 85% | 48.38 | 195 / 230 |
pancreas | 16% | 178.36 | 51 / 328 | 97% | 14.01 | 172 / 178 |
lymph node | 0% | 0 | 0 / 0 | 100% | 15.72 | 29 / 29 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.65 | 1 / 1 |
blood vessel | 99% | 2168.38 | 1317 / 1335 | 0% | 0 | 0 / 0 |
adipose | 96% | 1713.01 | 1161 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 24.14 | 43 / 45 |
eye | 0% | 0 | 0 / 0 | 84% | 12.26 | 67 / 80 |
spleen | 81% | 1108.07 | 195 / 241 | 0% | 0 | 0 / 0 |
muscle | 35% | 428.33 | 285 / 803 | 0% | 0 | 0 / 0 |
heart | 24% | 278.50 | 208 / 861 | 0% | 0 | 0 / 0 |
liver | 1% | 7.75 | 2 / 226 | 20% | 1.31 | 81 / 406 |
peripheral blood | 5% | 69.63 | 44 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051896 | Biological process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0001921 | Biological process | positive regulation of receptor recycling |
GO_0014898 | Biological process | cardiac muscle hypertrophy in response to stress |
GO_0031161 | Biological process | phosphatidylinositol catabolic process |
GO_0008344 | Biological process | adult locomotory behavior |
GO_0046856 | Biological process | phosphatidylinositol dephosphorylation |
GO_0048015 | Biological process | phosphatidylinositol-mediated signaling |
GO_2000145 | Biological process | regulation of cell motility |
GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0033137 | Biological process | negative regulation of peptidyl-serine phosphorylation |
GO_0072583 | Biological process | clathrin-dependent endocytosis |
GO_0048681 | Biological process | negative regulation of axon regeneration |
GO_0042532 | Biological process | negative regulation of tyrosine phosphorylation of STAT protein |
GO_2001135 | Biological process | regulation of endocytic recycling |
GO_0006661 | Biological process | phosphatidylinositol biosynthetic process |
GO_0055037 | Cellular component | recycling endosome |
GO_0005769 | Cellular component | early endosome |
GO_0031901 | Cellular component | early endosome membrane |
GO_0043025 | Cellular component | neuronal cell body |
GO_0030425 | Cellular component | dendrite |
GO_0045334 | Cellular component | clathrin-coated endocytic vesicle |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0030424 | Cellular component | axon |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0034595 | Molecular function | phosphatidylinositol phosphate 5-phosphatase activity |
GO_0034596 | Molecular function | phosphatidylinositol phosphate 4-phosphatase activity |
GO_0052833 | Molecular function | inositol monophosphate 4-phosphatase activity |
GO_0043812 | Molecular function | phosphatidylinositol-4-phosphate phosphatase activity |
GO_0008934 | Molecular function | inositol monophosphate 1-phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0052832 | Molecular function | inositol monophosphate 3-phosphatase activity |
Gene name | INPP5F |
Protein name | Inositol polyphosphate-5-phosphatase F Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) |
Synonyms | KIAA0966 MSTP047 MSTP007 SAC2 |
Description | FUNCTION: Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling . Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms . Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation . Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus . Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). . |
Accessions | A0A0J9YWP2 A0A0J9YYL5 ENST00000649251.1 ENST00000648262.1 ENST00000490818.1 ENST00000650305.1 A0A0J9YY79 A0A3B3IRT4 ENST00000631485.1 ENST00000648621.1 A0A3B3IS29 ENST00000649742.1 ENST00000649297.1 ENST00000648515.1 A0A3B3ITL0 ENST00000648661.1 ENST00000650409.1 [Q9Y2H2-4] A0A3B3ISI3 ENST00000647699.1 A0A3B3IS98 ENST00000637174.1 ENST00000650623.2 [Q9Y2H2-1] ENST00000369081.3 [Q9Y2H2-3] A0A3B3IU10 ENST00000631555.1 A0A0J9YVW6 A0A3B3IRJ9 ENST00000649454.1 A0A3B3ISK0 ENST00000631572.1 A0A3B3ITR9 ENST00000647933.1 Q9Y2H2 A0A1B0GUS5 A0A3B3ISG0 A0A3B3ISJ5 ENST00000649957.1 |