IMPDH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006183Biological processGTP biosynthetic process
GO_0006177Biological processGMP biosynthetic process
GO_0035578Cellular componentazurophil granule lumen
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003938Molecular functionIMP dehydrogenase activity
GO_0003676Molecular functionnucleic acid binding
GO_0046872Molecular functionmetal ion binding
GO_0000166Molecular functionnucleotide binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameIMPDH1
Protein nameInosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)
Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)
Inosine monophosphate dehydrogenase 1
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205)
SynonymsIMPDH
IMPD1
DescriptionFUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. .

AccessionsA0A3B3IRL5
C9K0R9
C9J029
ENST00000473463.1
P20839
ENST00000354269.9 [P20839-5]
F8WDE9
ENST00000480861.5 [P20839-4]
ENST00000348127.11 [P20839-3]
ENST00000338791.11 [P20839-6]
ENST00000469328.5
ENST00000489263.1
ENST00000419067.6 [P20839-7]
ENST00000470772.5
C9J381
ENST00000648462.1
H7C5T1
ENST00000496200.5 [P20839-2]
ENST00000497868.5