IL37 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL37 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ureter	0%	0	0 / 0	100%	2.63	1 / 1
skin	68%	1435.83	1238 / 1809	9%	0.66	41 / 472
intestine	1%	1.59	9 / 966	36%	1.91	188 / 527
lung	0%	0	0 / 578	33%	17.76	378 / 1155
pancreas	0%	0	0 / 328	28%	0.91	49 / 178
bladder	0%	0	0 / 21	26%	5.34	131 / 504
stomach	0%	0	0 / 359	17%	0.84	50 / 286
esophagus	0%	0	0 / 1445	13%	0.27	24 / 183
uterus	0%	0	0 / 170	13%	0.29	60 / 459
thymus	0%	0	0 / 653	10%	0.57	62 / 605
ovary	0%	0	0 / 180	5%	0.11	23 / 430
tonsil	0%	0	0 / 0	4%	0.06	2 / 45
lymph node	0%	0	0 / 0	3%	0.06	1 / 29
liver	0%	0	0 / 226	2%	0.03	9 / 406
breast	0%	0	0 / 459	2%	0.12	20 / 1118
brain	0%	0	0 / 2642	1%	0.01	7 / 705
kidney	0%	0	0 / 89	1%	0.01	5 / 901
prostate	0%	0	0 / 245	0%	0.00	1 / 502
adipose	0%	0.87	2 / 1204	0%	0	0 / 0
muscle	0%	0.31	1 / 803	0%	0	0 / 0
blood vessel	0%	1.04	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	0%	0	0 / 230
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0006955	Biological process	immune response
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0010628	Biological process	positive regulation of gene expression
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0050727	Biological process	regulation of inflammatory response
GO_0002437	Biological process	inflammatory response to antigenic stimulus
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005615	Cellular component	extracellular space
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity
GO_0005149	Molecular function	interleukin-1 receptor binding

Gene name	IL37
Protein name	Interleukin-37 (IL-37) (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1)
Synonyms	IL1H4 IL1F7 FIL1Z IL1RP1
Description	FUNCTION: Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. .
Accessions	ENST00000352179.7 [Q9NZH6-4] ENST00000353225.7 [Q9NZH6-3] ENST00000263326.8 [Q9NZH6-1] ENST00000311328.2 [Q9NZH6-2] Q9NZH6 ENST00000349806.7 [Q9NZH6-5]

IL37 report