IL36G report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL36G at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL36G at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0010628Biological processpositive regulation of gene expression
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0007267Biological processcell-cell signaling
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005125Molecular functioncytokine activity
GO_0005149Molecular functioninterleukin-1 receptor binding

IV. Literature review

[source]
Gene nameIL36G
Protein nameInterleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1)
Interleukin 36 gamma
SynonymsIL1F9
IL1H1
UNQ2456/PRO5737
IL1E
IL1RP2
DescriptionFUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. .

AccessionsC9J681
ENST00000259205.5 [Q9NZH8-1]
ENST00000376489.6 [Q9NZH8-2]
Q9NZH8
ENST00000447128.5