IL36B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL36B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL36B at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006955Biological processimmune response
GO_0010628Biological processpositive regulation of gene expression
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0005125Molecular functioncytokine activity
GO_0005149Molecular functioninterleukin-1 receptor binding

IV. Literature review

[source]
Gene nameIL36B
Protein nameInterleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2)
SynonymsIL1H2
IL1F8
DescriptionFUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6. .

AccessionsQ9NZH7
ENST00000327407.2 [Q9NZH7-2]
ENST00000259213.9 [Q9NZH7-1]