IKZF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032991Cellular componentprotein-containing complex
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0019904Molecular functionprotein domain specific binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameIKZF4
Protein nameZinc finger protein Eos (Ikaros family zinc finger protein 4)
IKAROS family zinc finger 4
SynonymsKIAA1782
ZNFN1A4
DescriptionFUNCTION: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). .

AccessionsA0A0G2JL44
F8VPL6
F8VW19
ENST00000262032.9 [Q9H2S9-1]
ENST00000547791.2
ENST00000551103.5
ENST00000547167.6 [Q9H2S9-1]
ENST00000431367.6 [Q9H2S9-1]
ENST00000552689.1
Q9H2S9