IGLC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0050853Biological processB cell receptor signaling pathway
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0005615Cellular componentextracellular space
GO_0071735Cellular componentIgG immunoglobulin complex
GO_0071745Cellular componentIgA immunoglobulin complex
GO_0072562Cellular componentblood microparticle
GO_0070062Cellular componentextracellular exosome
GO_0071753Cellular componentIgM immunoglobulin complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0071742Cellular componentIgE immunoglobulin complex
GO_0071738Cellular componentIgD immunoglobulin complex
GO_0003823Molecular functionantigen binding

IV. Literature review

[source]
Gene nameIGLC3
Protein nameImmunoglobulin lambda constant 3 (Ig lambda chain C region DOT) (Ig lambda chain C region NEWM) (Ig lambda-3 chain C regions)
Synonyms
DescriptionFUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen . .

AccessionsP0DOY3
ENST00000390325.2