IGF2BP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009653Biological processanatomical structure morphogenesis
GO_0006412Biological processtranslation
GO_0051028Biological processmRNA transport
GO_0007399Biological processnervous system development
GO_0001817Biological processregulation of cytokine production
GO_0017148Biological processnegative regulation of translation
GO_0070934Biological processCRD-mediated mRNA stabilization
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0045182Molecular functiontranslation regulator activity
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0048027Molecular functionmRNA 5'-UTR binding
GO_0005515Molecular functionprotein binding
GO_1990247Molecular functionN6-methyladenosine-containing RNA reader activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameIGF2BP3
Protein nameInsulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
Insulin like growth factor 2 mRNA binding protein 3
SynonymsKOC1
VICKZ3
IMP3
DescriptionFUNCTION: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability . Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD . Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. .

AccessionsENST00000258729.8 [O00425-1]
ENST00000421467.6
F8WD15
O00425
ENST00000619562.4 [O00425-2]