IFNL3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IFNL3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IFNL3 at tissue level.

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0098586Biological processcellular response to virus
GO_0050778Biological processpositive regulation of immune response
GO_0045071Biological processnegative regulation of viral genome replication
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0038196Biological processtype III interferon-mediated signaling pathway
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005102Molecular functionsignaling receptor binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIFNL3
Protein nameInterferon lambda 3 (Interleukin 28B (Interferon, lambda 3))
Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C)
SynonymsIL28B
IL28C
ZCYTO22
hCG_1997257
DescriptionFUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. .

AccessionsENST00000413851.3
A0A0C4DGW8
Q8IZI9
ENST00000613087.5
ENST00000709043.1