IFNL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IFNL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IFNL2 at tissue level.

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0098586Biological processcellular response to virus
GO_0050778Biological processpositive regulation of immune response
GO_0038196Biological processtype III interferon-mediated signaling pathway
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0002385Biological processmucosal immune response
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005102Molecular functionsignaling receptor binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIFNL2
Protein nameInterferon lambda-2 (IFN-lambda-2) (Cytokine Zcyto20) (Interleukin-28A) (IL-28A)
SynonymsZCYTO20
IL28A
DescriptionFUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. .

AccessionsQ8IZJ0
ENST00000709041.1
ENST00000331982.6