IFIT2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IFIT2 at tissue level.

III. Associated gene sets

GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0008637Biological processapoptotic mitochondrial changes
GO_0032091Biological processnegative regulation of protein binding
GO_0043065Biological processpositive regulation of apoptotic process
GO_0140374Biological processantiviral innate immune response
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameIFIT2
Protein nameInterferon induced protein with tetratricopeptide repeats 2
IFIT2 protein
Interferon-induced protein with tetratricopeptide repeats 2
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54)
SynonymsISG54
CIG-42
G10P2
IFI54
DescriptionFUNCTION: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. .

AccessionsENST00000680809.1
ENST00000679755.1
ENST00000681843.1
Q8IZ03
ENST00000611722.2
A0A7P0TAT2
ENST00000680381.1
A0A7P0T8B3
A0A087X279
ENST00000679734.1
P09913
ENST00000680954.1
A0A7P0T8R6
ENST00000679619.1
ENST00000371826.4
Q05DN2
ENST00000638108.1