IFI44L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0051607Biological processdefense response to virus
GO_0005575Cellular componentcellular_component
GO_0005737Cellular componentcytoplasm
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameIFI44L
Protein nameInterferon-induced protein 44-like
Interferon induced protein 44 like
Interferon induced protein 44 like (cDNA FLJ50321, highly similar to Homo sapiens interferon-induced protein 44-like (IFI44L), mRNA) (cDNA, FLJ79131, highly similar to Homo sapiens interferon-induced protein 44-like (IFI44L), mRNA)
SynonymsC1orf29
GS3686
DescriptionFUNCTION: Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity . During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion . Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate . Exhibits a low antiviral activity against hepatitis C virus . Acts also as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5 . .

AccessionsA0A7P0T9R5
A0A7P0Z4K2
ENST00000370751.10 [Q53G44-1]
ENST00000679848.1
B4E019
ENST00000681613.1
ENST00000476521.5
C9JPJ0
ENST00000679998.1
ENST00000680295.1
ENST00000450498.1
ENST00000452835.1
ENST00000681501.1
ENST00000459784.6
Q53G44
ENST00000680110.1
H7C1K6