ICOS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031295Biological processT cell costimulation
GO_0006955Biological processimmune response
GO_0098609Biological processcell-cell adhesion
GO_0002517Biological processT cell tolerance induction
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameICOS
Protein nameInducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD antigen CD278)
Inducible T-cell costimulator
SynonymsAILIM
hCG_1642889
DescriptionFUNCTION: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). .

FUNCTION: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. .

AccessionsQ9Y6W8
Q53QY6
ENST00000316386.11 [Q9Y6W8-1]
ENST00000435193.1 [Q9Y6W8-2]