HTR1B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HTR1B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTR1B at tissue level.

III. Associated gene sets

GO_0014059Biological processregulation of dopamine secretion
GO_0042756Biological processdrinking behavior
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0071502Biological processcellular response to temperature stimulus
GO_0050795Biological processregulation of behavior
GO_0045471Biological processresponse to ethanol
GO_0032229Biological processnegative regulation of synaptic transmission, GABAergic
GO_0042220Biological processresponse to cocaine
GO_0071312Biological processcellular response to alkaloid
GO_0046849Biological processbone remodeling
GO_0007268Biological processchemical synaptic transmission
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0099509Biological processregulation of presynaptic cytosolic calcium ion concentration
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0002031Biological processG protein-coupled receptor internalization
GO_0014063Biological processnegative regulation of serotonin secretion
GO_0007198Biological processadenylate cyclase-inhibiting serotonin receptor signaling pathway
GO_0042310Biological processvasoconstriction
GO_0051385Biological processresponse to mineralocorticoid
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0014053Biological processnegative regulation of gamma-aminobutyric acid secretion
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0051967Biological processnegative regulation of synaptic transmission, glutamatergic
GO_0005886Cellular componentplasma membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0044305Cellular componentcalyx of Held
GO_0005783Cellular componentendoplasmic reticulum
GO_0098666Cellular componentG protein-coupled serotonin receptor complex
GO_0099154Cellular componentserotonergic synapse
GO_0099626Molecular functionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0051378Molecular functionserotonin binding
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHTR1B
Protein name5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B)
5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B)
SynonymshCG_32414
HTR1DB
DescriptionFUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. .

FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. .

AccessionsP28222
ENST00000369947.5
X5D7I5