HSPBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006457Biological processprotein folding
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0005615Cellular componentextracellular space
GO_0005783Cellular componentendoplasmic reticulum
GO_0004857Molecular functionenzyme inhibitor activity
GO_0140313Molecular functionmolecular sequestering activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0000774Molecular functionadenyl-nucleotide exchange factor activity

IV. Literature review

[source]
Gene nameHSPBP1
Protein nameHSPA (Hsp70) binding protein 1
Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2)
SynonymsHSPBP
PP1845
DescriptionFUNCTION: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. .

AccessionsENST00000433386.7 [Q9NZL4-1]
ENST00000593263.5
K7EMM7
ENST00000587959.1
K7EQQ0
ENST00000587551.1
ENST00000255631.9 [Q9NZL4-1]
ENST00000587922.5 [Q9NZL4-1]
K7EN20
ENST00000588971.1
K7EKM6
ENST00000585698.1
K7EL16
K7ERT9
ENST00000585927.1
Q9NZL4