HSD17B4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008209Biological processandrogen metabolic process
GO_0060009Biological processSertoli cell development
GO_0036112Biological processmedium-chain fatty-acyl-CoA metabolic process
GO_0001649Biological processosteoblast differentiation
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0008210Biological processestrogen metabolic process
GO_0006635Biological processfatty acid beta-oxidation
GO_0036111Biological processvery long-chain fatty-acyl-CoA metabolic process
GO_0005778Cellular componentperoxisomal membrane
GO_0016020Cellular componentmembrane
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0003857Molecular function3-hydroxyacyl-CoA dehydrogenase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0018812Molecular function3-hydroxyacyl-CoA dehydratase activity
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0106386Molecular function(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO_0004300Molecular functionenoyl-CoA hydratase activity
GO_0044594Molecular function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO_0016853Molecular functionisomerase activity
GO_0033989Molecular function3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity

IV. Literature review

[source]
Gene nameHSD17B4
Protein nameHydroxysteroid dehydrogenase 4 isoform 4
Hydroxysteroid dehydrogenase 4 isoform 2
Epididymis secretory sperm binding protein (Hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_b) (Hydroxysteroid dehydrogenase 4 isoform 1)
Hydroxysteroid 17-beta dehydrogenase 4
Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]
Hydroxysteroid dehydrogenase 4 isoform 3
SynonymshCG_37330
EDH17B4
SDR8C1
DescriptionFUNCTION: Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. .

AccessionsENST00000509514.6
ENST00000683936.1
ENST00000647342.1
ENST00000515320.5 [P51659-3]
E7ER27
ENST00000513628.5
ENST00000682996.1
A0A2R8YDT8
A0A804HKU2
A0A804HK65
A0A2R8YD50
ENST00000647335.1
ENST00000645702.1
A0A804HIG8
E7ET17
ENST00000644146.1
ENST00000645099.1
A0A2R8YEG2
ENST00000510025.7 [P51659-1]
A0A0S2Z4Q6
A0A2R8Y7W2
A0A804HKB5
ENST00000683371.1
ENST00000645832.1
ENST00000682626.1
ENST00000682445.1
A0A804HLJ0
ENST00000643897.1
A0A0S2Z3Y5
A0A0S2Z460
ENST00000646554.1
P51659
A0A0S2Z4J1
A0A2R8Y7L2
ENST00000646355.1
ENST00000683996.1
A0A804HIR1
ENST00000442060.7
ENST00000646058.1
A0A2R8YCN2
ENST00000684214.1
A0A2R8YF39
ENST00000646590.1
E7EPL9
A0A804HK88
A0A2R8Y674
A0A2R8YF45
A0A804HKT2
ENST00000414835.7 [P51659-2]
ENST00000684160.1
ENST00000643250.1
ENST00000518349.6