Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 16 studies | 27% ± 9% | |
endothelial cell | 15 studies | 26% ± 11% | |
oligodendrocyte | 14 studies | 38% ± 16% | |
type II pneumocyte | 12 studies | 35% ± 13% | |
fibroblast | 11 studies | 23% ± 8% | |
mast cell | 10 studies | 28% ± 15% | |
type I pneumocyte | 10 studies | 27% ± 8% | |
glutamatergic neuron | 9 studies | 44% ± 27% | |
adipocyte | 9 studies | 36% ± 12% | |
astrocyte | 9 studies | 33% ± 18% | |
oligodendrocyte precursor cell | 9 studies | 30% ± 14% | |
epithelial cell | 7 studies | 35% ± 14% | |
basal cell | 7 studies | 25% ± 7% | |
GABAergic neuron | 7 studies | 46% ± 24% | |
alveolar macrophage | 6 studies | 30% ± 11% | |
microglial cell | 6 studies | 25% ± 9% | |
club cell | 6 studies | 25% ± 5% | |
classical monocyte | 5 studies | 24% ± 4% | |
neuron | 5 studies | 37% ± 18% | |
myeloid cell | 5 studies | 31% ± 8% | |
myofibroblast cell | 5 studies | 17% ± 1% | |
hepatocyte | 5 studies | 57% ± 16% | |
monocyte | 5 studies | 24% ± 10% | |
interneuron | 5 studies | 47% ± 26% | |
plasmacytoid dendritic cell | 5 studies | 22% ± 4% | |
conventional dendritic cell | 4 studies | 27% ± 9% | |
kidney loop of Henle epithelial cell | 4 studies | 19% ± 2% | |
cardiac muscle cell | 4 studies | 24% ± 2% | |
abnormal cell | 4 studies | 34% ± 19% | |
goblet cell | 4 studies | 18% ± 1% | |
hematopoietic precursor cell | 3 studies | 22% ± 6% | |
GABAergic interneuron | 3 studies | 24% ± 2% | |
B cell | 3 studies | 17% ± 1% | |
enterocyte | 3 studies | 18% ± 1% | |
ciliated cell | 3 studies | 27% ± 5% | |
dendritic cell | 3 studies | 29% ± 10% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 32% ± 14% | |
naive B cell | 3 studies | 17% ± 1% | |
pericyte | 3 studies | 20% ± 5% | |
transit amplifying cell | 3 studies | 27% ± 9% | |
smooth muscle cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 6216.09 | 2641 / 2642 | 100% | 47.08 | 704 / 705 |
prostate | 100% | 7621.28 | 245 / 245 | 100% | 103.43 | 501 / 502 |
liver | 100% | 15639.12 | 226 / 226 | 100% | 78.57 | 405 / 406 |
lung | 100% | 9379.83 | 577 / 578 | 100% | 30.55 | 1153 / 1155 |
stomach | 100% | 6350.11 | 359 / 359 | 100% | 34.07 | 285 / 286 |
esophagus | 100% | 5864.59 | 1444 / 1445 | 99% | 24.81 | 182 / 183 |
thymus | 100% | 15950.49 | 653 / 653 | 99% | 63.01 | 601 / 605 |
intestine | 100% | 6086.66 | 966 / 966 | 99% | 41.35 | 523 / 527 |
bladder | 100% | 6988.00 | 21 / 21 | 99% | 36.18 | 497 / 504 |
pancreas | 100% | 5954.22 | 327 / 328 | 99% | 30.88 | 176 / 178 |
uterus | 100% | 5430.93 | 170 / 170 | 98% | 33.96 | 451 / 459 |
kidney | 100% | 6319.27 | 89 / 89 | 98% | 35.09 | 884 / 901 |
breast | 100% | 9111.68 | 459 / 459 | 98% | 47.64 | 1094 / 1118 |
adrenal gland | 100% | 13657.38 | 258 / 258 | 98% | 36.98 | 225 / 230 |
ovary | 100% | 4920.12 | 180 / 180 | 97% | 18.42 | 418 / 430 |
skin | 100% | 7152.20 | 1809 / 1809 | 96% | 25.35 | 455 / 472 |
adipose | 100% | 9031.93 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 27.11 | 29 / 29 |
spleen | 100% | 5804.44 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 35.25 | 45 / 45 |
blood vessel | 100% | 5842.14 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 4290.53 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 95% | 6518.58 | 820 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 84% | 15.60 | 67 / 80 |
peripheral blood | 76% | 2429.43 | 706 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0008209 | Biological process | androgen metabolic process |
GO_0060009 | Biological process | Sertoli cell development |
GO_0036112 | Biological process | medium-chain fatty-acyl-CoA metabolic process |
GO_0001649 | Biological process | osteoblast differentiation |
GO_0000038 | Biological process | very long-chain fatty acid metabolic process |
GO_0008210 | Biological process | estrogen metabolic process |
GO_0006635 | Biological process | fatty acid beta-oxidation |
GO_0036111 | Biological process | very long-chain fatty-acyl-CoA metabolic process |
GO_0005778 | Cellular component | peroxisomal membrane |
GO_0016020 | Cellular component | membrane |
GO_0005777 | Cellular component | peroxisome |
GO_0005829 | Cellular component | cytosol |
GO_0005782 | Cellular component | peroxisomal matrix |
GO_0003857 | Molecular function | 3-hydroxyacyl-CoA dehydrogenase activity |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0018812 | Molecular function | 3-hydroxyacyl-CoA dehydratase activity |
GO_0004303 | Molecular function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
GO_0106386 | Molecular function | (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
GO_0004300 | Molecular function | enoyl-CoA hydratase activity |
GO_0044594 | Molecular function | 17-beta-hydroxysteroid dehydrogenase (NAD+) activity |
GO_0016853 | Molecular function | isomerase activity |
GO_0033989 | Molecular function | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity |
Gene name | HSD17B4 |
Protein name | Hydroxysteroid dehydrogenase 4 isoform 4 Hydroxysteroid dehydrogenase 4 isoform 2 Epididymis secretory sperm binding protein (Hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_b) (Hydroxysteroid dehydrogenase 4 isoform 1) Hydroxysteroid 17-beta dehydrogenase 4 Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] Hydroxysteroid dehydrogenase 4 isoform 3 |
Synonyms | hCG_37330 EDH17B4 SDR8C1 |
Description | FUNCTION: Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. . |
Accessions | ENST00000509514.6 ENST00000683936.1 ENST00000647342.1 ENST00000515320.5 [P51659-3] E7ER27 ENST00000513628.5 ENST00000682996.1 A0A2R8YDT8 A0A804HKU2 A0A804HK65 A0A2R8YD50 ENST00000647335.1 ENST00000645702.1 A0A804HIG8 E7ET17 ENST00000644146.1 ENST00000645099.1 A0A2R8YEG2 ENST00000510025.7 [P51659-1] A0A0S2Z4Q6 A0A2R8Y7W2 A0A804HKB5 ENST00000683371.1 ENST00000645832.1 ENST00000682626.1 ENST00000682445.1 A0A804HLJ0 ENST00000643897.1 A0A0S2Z3Y5 A0A0S2Z460 ENST00000646554.1 P51659 A0A0S2Z4J1 A0A2R8Y7L2 ENST00000646355.1 ENST00000683996.1 A0A804HIR1 ENST00000442060.7 ENST00000646058.1 A0A2R8YCN2 ENST00000684214.1 A0A2R8YF39 ENST00000646590.1 E7EPL9 A0A804HK88 A0A2R8Y674 A0A2R8YF45 A0A804HKT2 ENST00000414835.7 [P51659-2] ENST00000684160.1 ENST00000643250.1 ENST00000518349.6 |