HS3ST1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015015Biological processheparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO_0006024Biological processglycosaminoglycan biosynthetic process
GO_0005796Cellular componentGolgi lumen
GO_0008467Molecular function[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
GO_0008146Molecular functionsulfotransferase activity

IV. Literature review

[source]
Gene nameHS3ST1
Protein nameHeparan sulfate-glucosamine 3-sulfotransferase 1
Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1)
HS3ST1 protein
Synonyms3OST1
3OST
DescriptionFUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan . Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) . This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site . .

AccessionsE9PDE3
ENST00000002596.6
O14792
ENST00000514690.5
ENST00000510712.1
Q05CH3