HOXA1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HOXA1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HOXA1 at tissue level.

III. Associated gene sets

GO_0042473Biological processouter ear morphogenesis
GO_0048844Biological processartery morphogenesis
GO_0007605Biological processsensory perception of sound
GO_0021599Biological processabducens nerve formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0050795Biological processregulation of behavior
GO_0048839Biological processinner ear development
GO_0090103Biological processcochlea morphogenesis
GO_0050905Biological processneuromuscular process
GO_0090102Biological processcochlea development
GO_0048702Biological processembryonic neurocranium morphogenesis
GO_0009653Biological processanatomical structure morphogenesis
GO_0060840Biological processartery development
GO_0050890Biological processcognition
GO_0060876Biological processsemicircular canal formation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007634Biological processoptokinetic behavior
GO_0005634Cellular componentnucleus
GO_0000785Cellular componentchromatin
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHOXA1
Protein nameHomeo box A1
Homeobox A1
Homeobox protein Hox-A1 (Homeobox protein Hox-1F)
SynonymsHOX1F
tcag7.181
DescriptionFUNCTION: Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior . Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). .

AccessionsE7ERT8
ENST00000355633.5
ENST00000643460.2
P49639
A0A2R8Y4R9
A4D185