HOMER3 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell of lymphatic vessel	8 studies	27% ± 9%	Explore
endothelial cell	4 studies	30% ± 12%	Explore
classical monocyte	3 studies	31% ± 9%	Explore
macrophage	3 studies	23% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of HOMER3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2710.16	2638 / 2642	100%	19.78	704 / 705
thymus	100%	3334.68	653 / 653	100%	18.49	603 / 605
skin	100%	2178.01	1808 / 1809	99%	16.40	467 / 472
kidney	100%	3072.57	89 / 89	99%	15.31	890 / 901
ovary	100%	1208.50	180 / 180	99%	15.62	424 / 430
breast	100%	1685.15	458 / 459	98%	14.58	1100 / 1118
uterus	99%	1371.94	169 / 170	98%	19.77	450 / 459
prostate	100%	1437.99	244 / 245	97%	7.73	489 / 502
lung	100%	1610.96	576 / 578	94%	12.43	1080 / 1155
bladder	100%	1822.33	21 / 21	93%	17.31	469 / 504
esophagus	98%	1168.91	1410 / 1445	77%	12.52	140 / 183
stomach	97%	832.38	348 / 359	74%	5.76	213 / 286
intestine	97%	1245.25	933 / 966	68%	5.30	358 / 527
adrenal gland	100%	1836.28	258 / 258	59%	5.43	136 / 230
pancreas	58%	349.71	191 / 328	91%	11.22	162 / 178
eye	0%	0	0 / 0	100%	17.31	80 / 80
spleen	100%	7914.26	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	14.21	1 / 1
muscle	100%	4074.35	802 / 803	0%	0	0 / 0
adipose	100%	1910.77	1199 / 1204	0%	0	0 / 0
blood vessel	99%	1637.80	1325 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	13.71	43 / 45
heart	93%	942.14	804 / 861	0%	0	0 / 0
peripheral blood	78%	1236.16	721 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	66%	3.94	19 / 29
liver	13%	80.14	29 / 226	45%	5.14	183 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006605	Biological process	protein targeting
GO_2001256	Biological process	regulation of store-operated calcium entry
GO_0007216	Biological process	G protein-coupled glutamate receptor signaling pathway
GO_0070885	Biological process	negative regulation of calcineurin-NFAT signaling cascade
GO_0032703	Biological process	negative regulation of interleukin-2 production
GO_0045178	Cellular component	basal part of cell
GO_0005575	Cellular component	cellular_component
GO_0098978	Cellular component	glutamatergic synapse
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0030425	Cellular component	dendrite
GO_0035256	Molecular function	G protein-coupled glutamate receptor binding
GO_0019904	Molecular function	protein domain specific binding
GO_0005515	Molecular function	protein binding
GO_0042802	Molecular function	identical protein binding

Gene name	HOMER3
Protein name	Homer protein homolog 3 (Homer-3) Homer scaffold protein 3
Synonyms
Description	FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA . .
Accessions	M0QYF9 Q9NSC5 ENST00000433218.6 [Q9NSC5-2] M0R2U7 ENST00000221222.15 [Q9NSC5-2] M0R2T8 ENST00000599097.1 ENST00000594794.5 ENST00000392351.8 [Q9NSC5-1] ENST00000539827.5 [Q9NSC5-1] ENST00000542541.6 [Q9NSC5-1] ENST00000594439.5 [Q9NSC5-5] ENST00000596482.5 ENST00000600077.5 M0QZN1

HOMER3 report