HOMER1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090279Biological processregulation of calcium ion import
GO_0099173Biological processpostsynapse organization
GO_0003009Biological processskeletal muscle contraction
GO_0048741Biological processskeletal muscle fiber development
GO_0007206Biological processphospholipase C-activating G protein-coupled glutamate receptor signaling pathway
GO_0009967Biological processpositive regulation of signal transduction
GO_0007216Biological processG protein-coupled glutamate receptor signaling pathway
GO_0051966Biological processregulation of synaptic transmission, glutamatergic
GO_0007623Biological processcircadian rhythm
GO_0051262Biological processprotein tetramerization
GO_0007268Biological processchemical synaptic transmission
GO_1902950Biological processregulation of dendritic spine maintenance
GO_0035094Biological processresponse to nicotine
GO_0051928Biological processpositive regulation of calcium ion transport
GO_2001256Biological processregulation of store-operated calcium entry
GO_0048148Biological processbehavioral response to cocaine
GO_0035418Biological processprotein localization to synapse
GO_0051592Biological processresponse to calcium ion
GO_2001257Biological processregulation of cation channel activity
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0043034Cellular componentcostamere
GO_0030018Cellular componentZ disc
GO_0043198Cellular componentdendritic shaft
GO_0044309Cellular componentneuron spine
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0099524Cellular componentpostsynaptic cytosol
GO_0005737Cellular componentcytoplasm
GO_0060076Cellular componentexcitatory synapse
GO_0030424Cellular componentaxon
GO_0045177Cellular componentapical part of cell
GO_0035256Molecular functionG protein-coupled glutamate receptor binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0099186Molecular functionstructural constituent of postsynapse
GO_0097110Molecular functionscaffold protein binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0031802Molecular functiontype 5 metabotropic glutamate receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHOMER1
Protein nameHomer protein homolog 1 (Homer-1)
HOMER1F (Homer scaffold protein 1)
Homer homolog 1 (Drosophila)
SynonymsSYN47
DescriptionFUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA . .

AccessionsENST00000535690.1
ENST00000334082.11 [Q86YM7-1]
Q5U5K4
Q86YM7
Q86YM6
ENST00000508576.5 [Q86YM7-3]
ENST00000282260.10 [Q86YM7-2]