HELZ2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HELZ2 at tissue level.

III. Associated gene sets

GO_0035194Biological processregulatory ncRNA-mediated post-transcriptional gene silencing
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0043186Cellular componentP granule
GO_0005737Cellular componentcytoplasm
GO_0003677Molecular functionDNA binding
GO_0008859Molecular functionexoribonuclease II activity
GO_0005524Molecular functionATP binding
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003724Molecular functionRNA helicase activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameHELZ2
Protein name3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 3.6.4.13) (Helicase with zinc finger 2, transcriptional coactivator) (Helicase with zinc finger domain 2) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein)
SynonymsPRIC285
KIAA1769
DescriptionFUNCTION: Can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities . Shows a strong preference for pyrimidine over purine residues for its nuclease activity . Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA . .

AccessionsENST00000427522.6 [Q9BYK8-2]
Q9BYK8