HELQ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0010792Biological processDNA double-strand break processing involved in repair via single-strand annealing
GO_0097681Biological processdouble-strand break repair via alternative nonhomologous end joining
GO_0045003Biological processdouble-strand break repair via synthesis-dependent strand annealing
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0090734Cellular componentsite of DNA damage
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990518Molecular functionsingle-stranded 3'-5' DNA helicase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameHELQ
Protein nameHelicase, POLQ like
Helicase POLQ-like isoform 1
Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase)
Helicase POLQ-like isoform 2
SynonymsHEL308
DescriptionFUNCTION: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair . Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) . Possesses both DNA unwinding and annealing activities . Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA . Efficiently unwinds substrates containing 3' overhangs or a D-loop . In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing . Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences . .

AccessionsA0A0S2Z5X5
ENST00000295488.8 [Q8TDG4-1]
Q8TDG4
ENST00000510985.1
E3W982
ENST00000508591.5
A0A0S2Z5V3
E3W980