HCN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	13 studies	59% ± 27%	Explore
GABAergic neuron	9 studies	59% ± 28%	Explore
retinal rod cell	8 studies	58% ± 35%	Explore
retinal ganglion cell	7 studies	64% ± 20%	Explore
retinal cone cell	7 studies	69% ± 28%	Explore
interneuron	6 studies	61% ± 28%	Explore
neuron	4 studies	35% ± 15%	Explore
granule cell	4 studies	48% ± 12%	Explore
microglial cell	4 studies	40% ± 15%	Explore
endothelial cell	3 studies	48% ± 18%	Explore
GABAergic interneuron	3 studies	56% ± 22%	Explore
GABAergic amacrine cell	3 studies	38% ± 16%	Explore
OFF-bipolar cell	3 studies	57% ± 16%	Explore
ON-bipolar cell	3 studies	57% ± 15%	Explore
astrocyte	3 studies	46% ± 24%	Explore
glycinergic amacrine cell	3 studies	47% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	41% ± 26%	Explore
eye	6 studies	43% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	84%	1335.97	2230 / 2642	31%	1.70	221 / 705
adrenal gland	14%	47.52	36 / 258	62%	7.12	143 / 230
heart	45%	304.84	388 / 861	0%	0	0 / 0
pancreas	34%	78.98	111 / 328	2%	0.04	3 / 178
muscle	35%	155.68	278 / 803	0%	0	0 / 0
skin	1%	2.38	19 / 1809	19%	0.77	88 / 472
esophagus	10%	22.07	140 / 1445	0%	0	0 / 183
intestine	0%	0.65	4 / 966	5%	0.16	28 / 527
breast	4%	8.34	20 / 459	1%	0.02	9 / 1118
adipose	4%	9.05	52 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.25	3 / 80
lung	0%	0.44	1 / 578	3%	0.14	36 / 1155
uterus	1%	1.33	1 / 170	2%	0.06	9 / 459
stomach	1%	1.60	3 / 359	1%	0.04	4 / 286
liver	0%	0	0 / 226	2%	0.03	8 / 406
kidney	1%	1.47	1 / 89	1%	0.01	5 / 901
bladder	0%	0	0 / 21	1%	0.04	6 / 504
blood vessel	1%	1.59	11 / 1335	0%	0	0 / 0
thymus	0%	0.45	2 / 653	0%	0.01	2 / 605
ovary	0%	0	0 / 180	0%	0.00	1 / 430
prostate	0%	0	0 / 245	0%	0.00	1 / 502
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042391	Biological process	regulation of membrane potential
GO_0051867	Biological process	general adaptation syndrome, behavioral process
GO_0045176	Biological process	apical protein localization
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0003254	Biological process	regulation of membrane depolarization
GO_0046549	Biological process	retinal cone cell development
GO_0071320	Biological process	cellular response to cAMP
GO_0019228	Biological process	neuronal action potential
GO_0060078	Biological process	regulation of postsynaptic membrane potential
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0051289	Biological process	protein homotetramerization
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0030425	Cellular component	dendrite
GO_0045211	Cellular component	postsynaptic membrane
GO_0030424	Cellular component	axon
GO_0098855	Cellular component	HCN channel complex
GO_0030552	Molecular function	cAMP binding
GO_0005249	Molecular function	voltage-gated potassium channel activity
GO_0022843	Molecular function	voltage-gated monoatomic cation channel activity
GO_0005248	Molecular function	voltage-gated sodium channel activity
GO_0042802	Molecular function	identical protein binding
GO_0005267	Molecular function	potassium channel activity
GO_0005222	Molecular function	intracellularly cAMP-activated cation channel activity
GO_0140232	Molecular function	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HCN1
Protein name	Hyperpolarization activated cyclic nucleotide-gated potassium channel Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) Hyperpolarization activated cyclic nucleotide gated potassium channel 1
Synonyms	BCNG1
Description	FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions . Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. .
Accessions	Q86WJ6 A0A0U1RQR7 ENST00000673735.1 ENST00000634658.1 ENST00000303230.6 O60741 A0A669KB45

HCN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review