Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 22% ± 5% | |
fibroblast | 8 studies | 21% ± 6% | |
smooth muscle cell | 7 studies | 19% ± 4% | |
ciliated cell | 6 studies | 26% ± 6% | |
natural killer cell | 6 studies | 22% ± 4% | |
basal cell | 6 studies | 25% ± 7% | |
epithelial cell | 5 studies | 34% ± 13% | |
CD8-positive, alpha-beta T cell | 5 studies | 17% ± 2% | |
CD4-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
hematopoietic precursor cell | 4 studies | 27% ± 7% | |
glutamatergic neuron | 4 studies | 32% ± 16% | |
pericyte | 4 studies | 24% ± 4% | |
erythroblast | 4 studies | 36% ± 19% | |
macrophage | 4 studies | 19% ± 1% | |
astrocyte | 4 studies | 23% ± 3% | |
non-classical monocyte | 3 studies | 23% ± 7% | |
myofibroblast cell | 3 studies | 21% ± 5% | |
erythrocyte | 3 studies | 27% ± 15% | |
B cell | 3 studies | 22% ± 5% | |
oligodendrocyte | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 1644.71 | 180 / 180 | 100% | 22.04 | 430 / 430 |
esophagus | 100% | 1675.42 | 1443 / 1445 | 100% | 26.42 | 183 / 183 |
breast | 100% | 2231.37 | 459 / 459 | 100% | 33.26 | 1116 / 1118 |
pancreas | 100% | 1163.44 | 327 / 328 | 100% | 16.56 | 178 / 178 |
lung | 100% | 1857.36 | 576 / 578 | 100% | 25.46 | 1155 / 1155 |
uterus | 100% | 1603.56 | 170 / 170 | 99% | 33.34 | 456 / 459 |
stomach | 100% | 1482.91 | 359 / 359 | 99% | 20.82 | 284 / 286 |
prostate | 100% | 1579.15 | 245 / 245 | 99% | 25.53 | 498 / 502 |
brain | 99% | 938.81 | 2623 / 2642 | 100% | 21.88 | 704 / 705 |
thymus | 100% | 1832.37 | 653 / 653 | 99% | 21.48 | 598 / 605 |
intestine | 100% | 1741.57 | 966 / 966 | 99% | 21.18 | 520 / 527 |
bladder | 100% | 1699.38 | 21 / 21 | 98% | 21.83 | 496 / 504 |
skin | 100% | 2162.94 | 1809 / 1809 | 97% | 24.52 | 457 / 472 |
kidney | 100% | 1325.84 | 89 / 89 | 95% | 14.85 | 855 / 901 |
adrenal gland | 100% | 1988.98 | 258 / 258 | 91% | 13.87 | 210 / 230 |
liver | 97% | 749.35 | 219 / 226 | 94% | 10.90 | 383 / 406 |
blood vessel | 100% | 1991.33 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 28.29 | 29 / 29 |
muscle | 100% | 3011.56 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1941.44 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 33.96 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.38 | 1 / 1 |
adipose | 100% | 2043.69 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 1394.84 | 835 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 76% | 9.06 | 61 / 80 |
peripheral blood | 73% | 1613.54 | 674 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031509 | Biological process | subtelomeric heterochromatin formation |
GO_0051276 | Biological process | chromosome organization |
GO_0006475 | Biological process | internal protein amino acid acetylation |
GO_0006334 | Biological process | nucleosome assembly |
GO_0016363 | Cellular component | nuclear matrix |
GO_0032991 | Cellular component | protein-containing complex |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005739 | Cellular component | mitochondrion |
GO_0005634 | Cellular component | nucleus |
GO_0010485 | Molecular function | histone H4 acetyltransferase activity |
GO_0004402 | Molecular function | histone acetyltransferase activity |
GO_0043997 | Molecular function | histone H4K12 acetyltransferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0042393 | Molecular function | histone binding |
Gene name | HAT1 |
Protein name | Histone acetyltransferase 1 Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) |
Synonyms | KAT1 |
Description | FUNCTION: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair . Coordinates histone production and acetylation via H4 promoter binding . Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) . Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression . Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks . In addition, acetylates other substrates such as chromatin-related proteins . Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation . .; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. . |
Accessions | ENST00000412731.5 ENST00000264108.5 [O14929-1] O14929 ENST00000457761.6 F8WEW1 F8W9G7 |