HAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031509Biological processsubtelomeric heterochromatin formation
GO_0051276Biological processchromosome organization
GO_0006475Biological processinternal protein amino acid acetylation
GO_0006334Biological processnucleosome assembly
GO_0016363Cellular componentnuclear matrix
GO_0032991Cellular componentprotein-containing complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0043997Molecular functionhistone H4K12 acetyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding

IV. Literature review

[source]
Gene nameHAT1
Protein nameHistone acetyltransferase 1
Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)
SynonymsKAT1
DescriptionFUNCTION: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair . Coordinates histone production and acetylation via H4 promoter binding . Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) . Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression . Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks . In addition, acetylates other substrates such as chromatin-related proteins . Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation . .; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. .

AccessionsENST00000412731.5
ENST00000264108.5 [O14929-1]
O14929
ENST00000457761.6
F8WEW1
F8W9G7