H2BW1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H2BW1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H2BW1 at tissue level.

III. Associated gene sets

GO_0007076Biological processmitotic chromosome condensation
GO_0000781Cellular componentchromosome, telomeric region
GO_0031965Cellular componentnuclear membrane
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0030527Molecular functionstructural constituent of chromatin

IV. Literature review

[source]
Gene nameH2BW1
Protein nameHistone H2B type W-T (H2B histone family member W testis-specific) (H2B.W histone 1)
SynonymsH2BFWT
TH2B-175
DescriptionFUNCTION: Atypical histone H2B that can form nucleosomes structurally and dynamically indistinguishable from those containing conventional H2B. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling . However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes . May be important for telomere function and play a role in spermatogenesis . .

AccessionsENST00000217926.7 [Q7Z2G1-3]
Q7Z2G1