H2AC4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H2AC4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H2AC4 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0061644Biological processprotein localization to CENP-A containing chromatin
GO_0031507Biological processheterochromatin formation
GO_0070062Cellular componentextracellular exosome
GO_0000786Cellular componentnucleosome
GO_0043505Cellular componentCENP-A containing nucleosome
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003677Molecular functionDNA binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0005515Molecular functionprotein binding
GO_0030527Molecular functionstructural constituent of chromatin

IV. Literature review

[source]
Gene nameH2AC4
Protein nameHistone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
SynonymsHIST1H2AB;
HIST1H2AE
H2AC8
H2AFM
H2AFA
DescriptionFUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

AccessionsENST00000303910.5
P04908
ENST00000615868.2