GSDME report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0012501Biological processprogrammed cell death
GO_0055085Biological processtransmembrane transport
GO_0002839Biological processpositive regulation of immune response to tumor cell
GO_0042491Biological processinner ear auditory receptor cell differentiation
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0070269Biological processpyroptotic inflammatory response
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0098586Biological processcellular response to virus
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0022829Molecular functionwide pore channel activity
GO_1901612Molecular functioncardiolipin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGSDME
Protein nameGasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)]
DFNA5 protein
Deafness, autosomal dominant 5
Gasdermin E
SynonymsICERE1
DFNA5
DescriptionFUNCTION: [Gasdermin-E]: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis . This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis . .; FUNCTION: [Gasdermin-E, N-terminal]: Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively . After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukins (IL1B and IL16) and triggering pyroptosis . Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate . Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis . Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents . Exhibits bactericidal activity . Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity . Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression . May play a role in the p53/TP53-regulated cellular response to DNA damage . .; FUNCTION: [Gasdermin-E, N-terminal]: (Microbial infection) Pore-forming protein, which promotes maternal placental pyroptosis in response to Zika virus infection, contributing to adverse fetal outcomes. .

AccessionsA4FVA8
H7C0L2
A4FTY0
ENST00000409970.6 [O60443-3]
H7C147
ENST00000419307.6 [O60443-3]
ENST00000415480.5
ENST00000430096.1
ENST00000645220.1 [O60443-1]
H7BZJ0
ENST00000446822.6
C9JSR4
ENST00000414428.2
O60443
ENST00000342947.9 [O60443-1]