GRIN2C report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRIN2C at tissue level.

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0097553Biological processcalcium ion transmembrane import into cytosol
GO_0019722Biological processcalcium-mediated signaling
GO_1903539Biological processprotein localization to postsynaptic membrane
GO_0060079Biological processexcitatory postsynaptic potential
GO_0035235Biological processionotropic glutamate receptor signaling pathway
GO_0050885Biological processneuromuscular process controlling balance
GO_0098976Biological processexcitatory chemical synaptic transmission
GO_0060291Biological processlong-term synaptic potentiation
GO_0033058Biological processdirectional locomotion
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_0048167Biological processregulation of synaptic plasticity
GO_1904062Biological processregulation of monoatomic cation transmembrane transport
GO_0048168Biological processregulation of neuronal synaptic plasticity
GO_0098655Biological processmonoatomic cation transmembrane transport
GO_0007420Biological processbrain development
GO_0051968Biological processpositive regulation of synaptic transmission, glutamatergic
GO_0007215Biological processglutamate receptor signaling pathway
GO_0009611Biological processresponse to wounding
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0017146Cellular componentNMDA selective glutamate receptor complex
GO_1904315Molecular functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0004972Molecular functionNMDA glutamate receptor activity
GO_0022849Molecular functionglutamate-gated calcium ion channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGRIN2C
Protein nameGlutamate receptor
GRIN2C protein
Putative NMDtranscript(AltDon_e4)
Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)
Putative NMDtranscript(Del_e4)
SynonymshCG_29832
NMDAR2C
DescriptionFUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) . Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

AccessionsENST00000293190.10
A0A8D9PH81
A0A8D9PH82
A0A8D9PHA5
A0A8D9PHA4
ENST00000347612.4
A0A8D9PHA1
H0Y2V8
Q6PCC5
Q14957