GRHL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRHL1 at tissue level.

III. Associated gene sets

GO_0008544Biological processepidermis development
GO_0061436Biological processestablishment of skin barrier
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0045616Biological processregulation of keratinocyte differentiation
GO_0002934Biological processdesmosome organization
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGRHL1
Protein nameGrainyhead like transcription factor 1
Grainyhead like transcription factor 1 (cDNA FLJ51493, highly similar to Grainyhead-like protein 1)
Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32)
SynonymsLBP32
MGR
TFCP2L2
DescriptionFUNCTION: Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' . Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). May play a role in regulating glucose homeostasis and insulin signaling. .; FUNCTION: [Isoform 1]: Functions as a transcription activator. .; FUNCTION: [Isoform 2]: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed. .

AccessionsENST00000439493.5
Q9NZI5
ENST00000472167.5 [Q9NZI5-3]
ENST00000324907.14 [Q9NZI5-1]
ENST00000464418.5
ENST00000480736.1
F8WFB0
B7Z1S6
ENST00000405379.6 [Q9NZI5-2]
C9JYY8