Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| myofibroblast cell | 4 studies | 29% ± 8% | |
| smooth muscle cell | 4 studies | 57% ± 12% | |
| glutamatergic neuron | 4 studies | 35% ± 5% | |
| retinal bipolar neuron | 3 studies | 18% ± 3% | |
| rod bipolar cell | 3 studies | 29% ± 5% | |
| hepatocyte | 3 studies | 44% ± 17% | |
| GABAergic neuron | 3 studies | 37% ± 7% |
Insufficient scRNA-seq data for expression of GREM2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 80% | 538.09 | 197 / 245 | 94% | 11.07 | 470 / 502 |
| intestine | 99% | 3136.96 | 959 / 966 | 61% | 3.38 | 322 / 527 |
| liver | 100% | 2765.23 | 226 / 226 | 59% | 11.40 | 238 / 406 |
| stomach | 96% | 1145.41 | 345 / 359 | 59% | 4.57 | 169 / 286 |
| esophagus | 94% | 915.07 | 1353 / 1445 | 43% | 2.28 | 79 / 183 |
| bladder | 86% | 801.10 | 18 / 21 | 36% | 1.82 | 179 / 504 |
| breast | 68% | 456.34 | 310 / 459 | 41% | 1.45 | 463 / 1118 |
| brain | 59% | 407.60 | 1563 / 2642 | 48% | 2.09 | 340 / 705 |
| ovary | 87% | 785.95 | 157 / 180 | 13% | 0.28 | 56 / 430 |
| uterus | 73% | 969.31 | 124 / 170 | 25% | 2.72 | 117 / 459 |
| lung | 50% | 147.98 | 287 / 578 | 38% | 3.15 | 444 / 1155 |
| skin | 82% | 686.81 | 1476 / 1809 | 5% | 0.46 | 25 / 472 |
| muscle | 65% | 774.91 | 518 / 803 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0.53 | 1 / 328 | 52% | 4.08 | 93 / 178 |
| spleen | 46% | 204.97 | 112 / 241 | 0% | 0 | 0 / 0 |
| thymus | 23% | 69.05 | 153 / 653 | 20% | 0.98 | 122 / 605 |
| adrenal gland | 21% | 67.22 | 54 / 258 | 14% | 5.20 | 33 / 230 |
| blood vessel | 32% | 154.08 | 424 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 20% | 0.41 | 9 / 45 |
| adipose | 18% | 65.62 | 216 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 12% | 99.80 | 11 / 89 | 5% | 0.72 | 48 / 901 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.29 | 7 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.07 | 2 / 29 |
| peripheral blood | 1% | 1.66 | 7 / 929 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.21 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010172 | Biological process | embryonic body morphogenesis |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0060300 | Biological process | regulation of cytokine activity |
| GO_0048263 | Biological process | determination of dorsal identity |
| GO_0038098 | Biological process | sequestering of BMP from receptor via BMP binding |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0008201 | Molecular function | heparin binding |
| GO_0036122 | Molecular function | BMP binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0048018 | Molecular function | receptor ligand activity |
| Gene name | GREM2 |
| Protein name | Gremlin-2 (Cysteine knot superfamily 1, BMP antagonist 2) (DAN domain family member 3) (Protein related to DAN and cerberus) |
| Synonyms | DAND3 PRDC CKTSF1B2 |
| Description | FUNCTION: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. . |
| Accessions | Q9H772 ENST00000318160.5 |
