GPSM1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPSM1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPSM1 at tissue level.

III. Associated gene sets

GO_1905098Biological processnegative regulation of guanyl-nucleotide exchange factor activity
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0007399Biological processnervous system development
GO_0034260Biological processnegative regulation of GTPase activity
GO_0016239Biological processpositive regulation of macroautophagy
GO_0030154Biological processcell differentiation
GO_0000139Cellular componentGolgi membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005092Molecular functionGDP-dissociation inhibitor activity
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPSM1
Protein nameG protein signaling modulator 1
G-protein-signaling modulator 1 (Activator of G-protein signaling 3)
SynonymsAGS3
DescriptionFUNCTION: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. .

AccessionsENST00000616132.4
ENST00000429455.5 [Q86YR5-2]
ENST00000291775.3 [Q86YR5-2]
A0A087WVF5
A0A0A0MRC4
ENST00000440944.6
A0A0A0MSK4
Q86YR5
ENST00000392944.5 [Q86YR5-2]
ENST00000354753.7