GNAT3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GNAT3 at tissue level.

III. Associated gene sets

GO_0050917Biological processsensory perception of umami taste
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0035094Biological processresponse to nicotine
GO_0001580Biological processdetection of chemical stimulus involved in sensory perception of bitter taste
GO_0050916Biological processsensory perception of sweet taste
GO_0016324Cellular componentapical plasma membrane
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0032991Cellular componentprotein-containing complex
GO_0001917Cellular componentphotoreceptor inner segment
GO_0005930Cellular componentaxoneme
GO_0005737Cellular componentcytoplasm
GO_0005834Cellular componentheterotrimeric G-protein complex
GO_0031683Molecular functionG-protein beta/gamma-subunit complex binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0005525Molecular functionGTP binding
GO_0046872Molecular functionmetal ion binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGNAT3
Protein nameGuanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain)
Synonyms
DescriptionFUNCTION: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. .

AccessionsA8MTJ3
ENST00000398291.4