GGH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046900Biological processtetrahydrofolylpolyglutamate metabolic process
GO_0035578Cellular componentazurophil granule lumen
GO_0005773Cellular componentvacuole
GO_0005615Cellular componentextracellular space
GO_1904724Cellular componenttertiary granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0042470Cellular componentmelanosome
GO_0035580Cellular componentspecific granule lumen
GO_0005634Cellular componentnucleus
GO_0034722Molecular functiongamma-glutamyl-peptidase activity
GO_0005515Molecular functionprotein binding
GO_0008242Molecular functionomega peptidase activity
GO_0008238Molecular functionexopeptidase activity

IV. Literature review

[source]
Gene nameGGH
Protein namefolate gamma-glutamyl hydrolase (EC 3.4.19.9)
Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)
Gamma-glutamyl hydrolase
Synonyms
DescriptionFUNCTION: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate . May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. .

AccessionsENST00000677482.1
ENST00000677459.1
A0A7I2YQQ3
A0A7I2V5P2
A0A7I2V5M0
Q92820
A0A7I2V431
ENST00000260118.7
ENST00000677919.1
ENST00000679326.1
A0A7I2V5X9
ENST00000518113.2