GFPT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006048Biological processUDP-N-acetylglucosamine biosynthetic process
GO_0006002Biological processfructose 6-phosphate metabolic process
GO_0032922Biological processcircadian regulation of gene expression
GO_0006541Biological processglutamine metabolic process
GO_0006047Biological processUDP-N-acetylglucosamine metabolic process
GO_0006487Biological processprotein N-linked glycosylation
GO_0006112Biological processenergy reserve metabolic process
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0004360Molecular functionglutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO_0097367Molecular functioncarbohydrate derivative binding

IV. Literature review

[source]
Gene nameGFPT1
Protein nameglutamine--fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16)
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1)
Glutamine--fructose-6-phosphate transaminase 1
SynonymsGFPT
GFAT
DescriptionFUNCTION: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling . .

AccessionsA0A6I8PRT6
ENST00000494201.1
A0A6I8PTT9
ENST00000674438.1
ENST00000361060.5 [Q06210-2]
A0A6I8PRN4
ENST00000357308.9 [Q06210-1]
ENST00000674507.1
Q06210