GEMIN5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000387Biological processspliceosomal snRNP assembly
GO_0006412Biological processtranslation
GO_0065003Biological processprotein-containing complex assembly
GO_0006417Biological processregulation of translation
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0032797Cellular componentSMN complex
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0034719Cellular componentSMN-Sm protein complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0097504Cellular componentGemini of coiled bodies
GO_0034718Cellular componentSMN-Gemin2 complex
GO_0005634Cellular componentnucleus
GO_0017069Molecular functionsnRNA binding
GO_0000340Molecular functionRNA 7-methylguanosine cap binding
GO_0030619Molecular functionU1 snRNA binding
GO_0030622Molecular functionU4atac snRNA binding
GO_0043022Molecular functionribosome binding
GO_0003723Molecular functionRNA binding
GO_0030621Molecular functionU4 snRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGEMIN5
Protein nameGEMIN5 protein
Alternative protein GEMIN5
Gem-associated protein 5 (Gemin5)
Synonyms
DescriptionFUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs . Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP . To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate . Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex . Binds to the 7-methylguanosine cap of RNA molecules . Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability . May play a role in the regulation of protein synthesis via its interaction with ribosomes . .

AccessionsL8ECG2
L8E9U3
ENST00000285873.8
Q8TEQ6
Q58EZ8
B7ZLC9